Hegel

Semantic Scientific Computing with Turbulance DSL

Revolutionary platform where scientists express complete experimental methodologies as executable Turbulance scripts. Hegel executes the scientific method itself with genuine semantic understanding, not just statistical processingβ€”transforming how we conduct computational science.

Spectral Match
Sequence Similarity
Pathway Context

Turbulance DSL: Executable Scientific Method

The Paradigm Shift

Instead of scientists using Hegel as just a processing tool, they write their entire experimental methodology as Turbulance scripts, and Hegel executes the scientific method itself with genuine understanding of what each step means scientifically.

Traditional Approach

πŸ“Š Statistical Processing

πŸ”’ Data β†’ Numbers β†’ Results

❌ No semantic understanding

Turbulance Revolution

🧠 Semantic Understanding

πŸ”¬ Hypothesis β†’ Execution β†’ Insight

βœ… Genuine scientific reasoning

Four-File Semantic System

.trb

Main Script

Core experimental methodology with semantic operations

.fs

Consciousness Visualization

Real-time semantic understanding visualization

.ghd

Dependencies

Intelligence module orchestration and data sources

.hre

Decision Logging

Metacognitive decision tracking and authenticity validation

Example: Diabetes Biomarker Discovery

hypothesis "Type 2 diabetes progression involves metabolic pathway dysregulation detectable through multi-omics integration"

# Semantic data integration with V8 intelligence
funxn load_patient_data():
    proteomics_data = spectacular.load_ms_data("patients/*.mzML")
    genomics_data = mzekezeke.load_variants("patients/*.vcf")
    metabolomics_data = hatata.load_metabolites("patients/*.csv")
    
    # Semantic integration, not just concatenation
    return diggiden.integrate_modalities(proteomics_data, genomics_data, metabolomics_data)

# Proposition with semantic understanding
proposition diabetes_biomarkers = nicotine.discover_biomarkers(
    patient_data,
    phenotype="diabetes_progression",
    semantic_context="metabolic_dysregulation"
)

# Motion: Execute with genuine understanding
motion validate_biomarkers:
    for biomarker in diabetes_biomarkers:
        # Semantic validation, not just statistical
        authenticity = pungwe.validate_authenticity(biomarker)
        biological_relevance = champagne.assess_relevance(biomarker, "diabetes")
        
        if authenticity > 0.8 and biological_relevance > 0.7:
            yield biomarker

V8 Intelligence Network

πŸ€–

Mzekezeke

ML workhorse with semantic learning

βš”οΈ

Diggiden

Adversarial authenticity validation

🎯

Hatata

Decision processes with genuine understanding

✨

Spectacular

Anomaly detection with semantic context

🚬

Nicotine

Biomarker discovery with biological insight

🌊

Pungwe

Cross-modal integration and validation

🎈

Zengeza

Dream processing for novel insights

🍾

Champagne

Biological relevance assessment

Getting Started with Turbulance

# Compile and execute Turbulance script
cargo run --bin hegel compile-turbulance --project diabetes_study/

# Execute with semantic understanding
cargo run --bin hegel execute-turbulance --script diabetes_study.trb

# API integration
curl -X POST "http://localhost:8080/turbulance/compile-and-execute" \
  -H "Content-Type: application/json" \
  -d '{"script": "hypothesis \"...\"\nfunxn load_data(): ..."}'

The Problem with Binary Evidence

Traditional Approach

Evidence: 0.7
β†’
Classification: TRUE
Evidence: 0.4
β†’
Classification: FALSE

Forces continuous biological evidence into binary classifications, losing critical uncertainty information.

Hegel's Innovation

Evidence: 0.7
Medium: 0.3
High: 0.7
Evidence: 0.4
Low: 0.6
Medium: 0.4

Preserves the continuous nature of biological evidence with fuzzy membership degrees and uncertainty quantification.

Federated Evidence Collaboration

The Data Access Challenge

Most valuable biological evidence is distributed across institutions and often inaccessible due to:

  • Privacy regulations (HIPAA, GDPR)
  • Competitive concerns in pharmaceutical research
  • Institutional data governance policies
  • Technical barriers to data sharing

Federated Learning Solution

Inspired by Bloodhound, Hegel enables:

  • Local-First Processing: Data never leaves its source
  • Pattern-Only Sharing: Only learned insights are shared
  • Zero-Configuration: Automatic peer discovery and setup
  • Privacy-Preserving: Differential privacy and secure aggregation

Federated Architecture

Institution A

Local Evidence (Private)
Fuzzy-Bayesian Engine
Pattern Extraction

Institution B

Local Evidence (Private)
Fuzzy-Bayesian Engine
Pattern Extraction

Institution C

Local Evidence (Private)
Fuzzy-Bayesian Engine
Pattern Extraction

Federated Aggregation

Patterns Only - No Raw Data

Hybrid Fuzzy-Bayesian Evidence System

πŸ”¬

Fuzzy Logic Framework

Continuous membership functions replace binary classifications

  • Triangular, Gaussian, Trapezoidal, Sigmoid functions
  • Linguistic variables: very_low β†’ very_high
  • T-norms and S-norms for evidence combination
🧠

Bayesian Networks

Probabilistic reasoning with fuzzy evidence integration

  • Hybrid fuzzy-Bayesian inference
  • Evidence relationship modeling
  • Posterior probability calculation
🌐

Evidence Networks

Learn relationships and predict missing evidence

  • Automatic relationship discovery
  • Missing evidence prediction
  • Network coherence optimization

Specialized Intelligence Modules

πŸ€–

Mzekezeke - ML Workhorse

Primary predictive engine with ensemble methods

  • Multi-modal biological data learning
  • Continuous model adaptation
  • Automated feature engineering
βš”οΈ

Diggiden - Adversarial System

Persistent vulnerability detection and testing

  • Adversarial robustness testing
  • Evidence consistency auditing
  • Federated security monitoring
🎯

Hatata - Decision System

Markov decision processes with utility optimization

  • Probabilistic state modeling
  • Multi-objective optimization
  • Adaptive policy learning
✨

Spectacular - Anomaly Handler

Specialized processing for extraordinary findings

  • Multi-method anomaly detection
  • Novel pattern recognition
  • Extraordinary event classification

Mathematical Foundation

Hybrid Fuzzy-Bayesian Inference:
P(identity|evidence) = ∫ ΞΌ(evidence) Γ— P(evidence|identity) Γ— P(identity) dΞΌ

ΞΌ(evidence): Fuzzy membership degree of evidence

P(evidence|identity): Likelihood weighted by fuzzy confidence

P(identity): Network-based priors from evidence relationships

System Architecture

Frontend Layer

React UI
3D Visualization
Network Graphs

API Layer

FastAPI Backend
JWT Auth
Fuzzy Endpoints

Intelligence Modules

Mzekezeke ML
Diggiden Adversarial
Hatata MDP
Spectacular Anomaly

Core Engine

Rust Core
Fuzzy Logic
Bayesian Networks

Data Layer

Neo4j Graph DB
Reactome
Interactome

Performance Advantages

10-100x
Faster Processing
Rust core vs Python
30-day
Temporal Decay
Evidence reliability modeling
Multi-threaded
Parallel Processing
SIMD optimizations
Zero-copy
Memory Efficiency
Optimized data handling

Research Applications

🧬

Proteomics

Continuous confidence scoring for protein identifications with temporal decay modeling for aging spectral libraries.

  • Multi-dimensional uncertainty analysis
  • Complex sample processing
  • Spectral library management
βš—οΈ

Metabolomics

Fuzzy structural similarity assessment with continuous membership in metabolic pathways.

  • Uncertainty-aware biomarker discovery
  • Pathway membership analysis
  • Structural similarity scoring
πŸ”¬

Multi-omics Integration

Fuzzy evidence fusion across genomics, transcriptomics, and proteomics with coherent uncertainty propagation.

  • Cross-platform evidence integration
  • Missing data prediction
  • Uncertainty propagation
🌐

Systems Biology

Evidence-based pathway reconstruction with network coherence optimization and uncertainty-aware modeling.

  • Pathway reconstruction
  • Network optimization
  • Systems-level analysis
πŸ’Š

Precision Medicine

Patient-specific evidence networks with uncertainty-aware biomarker validation and personalized treatment pathways.

  • Personalized medicine
  • Biomarker validation
  • Treatment optimization
πŸ§ͺ

Drug Discovery

Target identification with confidence bounds and evidence-based drug-target interaction prediction.

  • Target identification
  • Drug-target interactions
  • Compound screening

Getting Started

Prerequisites

πŸ¦€
Rust 1.70+

For core engine development

🐍
Python 3.8+

For backend development

πŸ“¦
Node.js 18+

For frontend development

🐳
Docker

For containerized deployment

Quick Start

# Clone the repository
git clone https://github.com/fullscreen-triangle/hegel.git
cd hegel

# Run setup script
chmod +x scripts/*.sh
./scripts/setup.sh

# Start development environment
./scripts/dev.sh

# Access the application
# Frontend: http://localhost:3000
# API Docs: http://localhost:8080/docs
# Neo4j Browser: http://localhost:7474

Manual Development Setup

# Navigate to core directory
cd core

# Build the Rust core engine
cargo build --release

# Run fuzzy-Bayesian tests
cargo test

# Development with hot reloading
cargo watch -x check -x test
# Navigate to backend directory
cd backend

# Create virtual environment
python -m venv venv
source venv/bin/activate

# Install dependencies
pip install -r requirements.txt

# Run the API
uvicorn app.main:app --reload
# Navigate to frontend directory
cd frontend

# Install dependencies
yarn install

# Start development server
yarn dev

Documentation & Resources

πŸš€

Turbulance DSL Guide

Complete guide to writing executable scientific methods

Learn Turbulance β†’
πŸ“š

API Documentation

Comprehensive API reference with fuzzy evidence endpoints

View API Docs β†’
πŸ”¬

Scientific Background

Mathematical foundations of fuzzy-Bayesian evidence systems

Learn More β†’
πŸ—οΈ

Architecture Guide

Detailed system architecture and component interactions

Explore Architecture β†’
πŸš€

Deployment Guide

Production deployment with Docker and Nginx

Deploy Now β†’
πŸ§ͺ

Research Examples

Real-world applications and case studies

View Examples β†’
🀝

Contributing

Guidelines for contributing to the project

Contribute β†’